Based on the game from Black Lilith, the narrative follows special agents Kirisawa Rei and Izumi Fuko. Set in Tokyo during the year 2054, these two work as a unit known as Mayaku Tokuso. Their duty involves investigating drug-related crimes and dismantling the associated syndicates. The pair have endured many violent encounters as an effective team. Intelligence later leads them to Shinjuku, a district notorious for being the city's most hazardous area. This location is rumored to contain the hidden base of a long-sought syndicate called 12 Angels. However, this information proves to be a calculated trap orchestrated by the boss Kiryu, who seeks revenge against the agents.
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